C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C12N 15/00 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2700941
A method is described wherein prostate or breast cancer is detected by quantifying a 3.4-kilobase deletion in the mitochondrial DNA (mtDNA) of a test sample. The deletion is located between nucleotides 10744-14124 of the mitochondrial genome. An increase in the amount of the deletion relative to the amount of the deletion in non-cancerous prostate and breast tissue is indicative of prostate and breast cancer, respectively.
L'invention porte sur un procédé suivant lequel un cancer de la prostate ou du sein est détecté par la quantification d'une délétion de 3,4 kilobases dans l'ADN mitochondrial (ADNmt) d'un échantillon d'essai. La délétion est située entre les nucléotides 10744 et 14124 du génome mitochondrial. Une augmentation de la quantité de délétion par rapport à la quantité de délétion dans le tissu non cancéreux de la prostate et du sein est indicative d'un cancer respectivement de la prostate et du sein.
Creed Jennifer
Dakubo Gabriel
Maggrah Andrea
Parr Ryan
Reguly Brian
Blake Cassels & Graydon Llp
Genesis Genomics Inc.
Mitomics Inc.
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