3-{4-methyl-3[methyl-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-amino...

Details 3-{4-methyl-3[methyl-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-amino... 3-{4-methyl-3[methyl-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-amino...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2469350

This invention relates to a novel amorphous and crystallline forms of 3- {(3R,4R)-4-methyl-3-[methyl-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-3-oxo-propionitrile mono citrate salt, useful as inhibitors of protein kinases, and to their methods of preparation.

L'invention concerne de nouvelles formes amorphes et cristallines de monocitrate de 3-{(3R,4R)-4-méthyl-3-[méthyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-pipéridin-1-yl}-3-oxo-propionitrile qui sont utilisées comme inhibiteurs de protéines kinase, ainsi que leurs procédés de préparation.

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