C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/404 (2006.01) A61P 35/00 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01)
Patent
CA 2462950
The present invention relates to certain 3-[4-(substituted Heterocyclyl)- pyrrol-2-ylmethylidene]-2-Indolinone derivatives that inhibit kinases, in particular VEGFR and/or PDGFR kinases. Pharmaceutical compositions comprising these compounds, methods of treating diseases mediated by kinases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing them are also disclosed.
La présente invention porte sur certains dérivés de 3-[4-(substitué hétérocyclyl)-pyrrol-2-ylméthylidène]-2-Indolinone qui inhibent les kinases, notamment les kinases VEGFR et/ou PDGFR. L'invention porte également sur des compositions pharmaceutiques comprenant ces composés, sur des procédés de traitement des maladies induites par les kinases qui utilisent ces composés et sur leurs procédés de préparation.
Guan Huiping
Liang Congxin
Mattson Matthew
Tang Peng Cho
Vojkovsky Tomas
Osler Hoskin & Harcourt Llp
Sugen Inc.
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