3, 4 - substituted piperidine derivatives as renin inhibitors

Details 3, 4 - substituted piperidine derivatives as renin inhibitors 3, 4 - substituted piperidine derivatives as renin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4545 (2006.01) A61P 9/00 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2722734

The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position oxopyridine and having the formula (I). The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.

La présente invention concerne des composés inhibiteurs de la rénine à base de pipéridinyle substitués en 3,4 portant en position 4 de loxopyridine et ayant la formule (I). Linvention concerne en outre des compositions pharmaceutiques contenant lesdits composés, ainsi que leur utilisation dans le traitement dévènements cardiovasculaires et dinsuffisance rénale.

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