3,4 - substituted piperidine derivatives as renin inhibitors

Details 3,4 - substituted piperidine derivatives as renin inhibitors 3,4 - substituted piperidine derivatives as renin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4545 (2006.01) A61P 9/00 (2006.01) A61P 13/12 (2006.01)

Patent

CA 2747279

The present invention re-lates to 3,4-substituted piperidinyl - based renin inhibitor compounds bearing at 4-po-sition oxopyridine or lsoquinolone and hav-ing the formula (I): wherein S is Formula (IIa) or Formula (IIb). The invention further relates to pharmaceutical compositions con-taining said compounds, as well as their use in treating cardiovascular events and renal insufficiency.

Cette invention concerne des composés à base de pipéridinyle substitué en 3,4 et inhibiteurs de rénine portant, en position 4, de loxopyridine ou de lisoquinolone et de formule générale (I), S étant de formule (IIa) ou de formule (IIb). Linvention concerne par ailleurs des compositions pharmaceutiques contenant lesdits composés, ainsi que leur utilisation pour traiter les événements cardiovasculaires et linsuffisance rénale.

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