3, 4 - substituted piperidine derivatives as renin inhibitors

Details 3, 4 - substituted piperidine derivatives as renin inhibitors 3, 4 - substituted piperidine derivatives as renin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4709 (2006.01)

Patent

CA 2724756

The present invention relates to 3,4-substituted piperidinyl - based renin inhibitor compounds bearing at 4-position Isoqumolone and having the Formula (I) : The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.

La présente invention concerne des composés inhibiteurs de la rénine, à base de pipéridinyle 3,4-substituée, porteurs d'isoquinolone en position 3, et représentés par la formule (I). L'invention concerne également des compositions contenant ces composés, ainsi que leur utilisation en cas d'accidents cardiovasculaires et d'insuffisance rénale.

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