3,4-substituted pyrazoles for the treatment of inflammation

Details 3,4-substituted pyrazoles for the treatment of inflammation 3,4-substituted pyrazoles for the treatment of inflammation

C - Chemistry, Metallurgy

07

D

C07D 231/10 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 231/12 (2006.01) C07D 401/00 (2006.01) C07D 403/02 (2006.01) C07D 405/02 (2006.01) C07D 409/02 (2006.01) C07D 413/02 (2006.01) C07D 417/02 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2195123

A class of pyrazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula (II), wherein R1 is selected from alkyl, aralkyl, alkynyl, cyanoalkyl, carboxyalkyl, aminocarbonylalkyl, arylaminocarbonylalkyl, heterocyclicalkyl, and alkoxycarbonylalkyl; wherein R3 is aryl optionally substituted at a substitutable position with one or more radicals independently selected from halo, alkylthio, alkylsulfinyl, alkyl, cyano, carboxyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, N-alkyl-N-arylaminocarbonyl, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkoxy, amino, alkylamino, arylamino, heterocyclo and nitro; wherein R4 is haloalkyl; and wherein R5 is selected from alkyl and amino; or a pharmaceutically acceptable salt thereof.

On décrit une classe de composés ou leurs sels pharmacologiquement acceptables, à base de pyrazolyle, utiles pour traiter des inflammations et des troubles en découlant. Les composés présentant un intérêt particulier sont définis par la formule (II), où R?1¿ est choisi parmi alkyle, arakyle, alkynyle, cyanoalkyle, carboxyalkyle, aminocarbonylalkyle, arylaminocarbonylalkyle, alkyle hétérocyclique et alcoxycarbonylalkyle; R?3¿ représente aryle éventuellement substitué en une position substituable avec un ou plusieurs radicaux choisis indépendemment parmi halo, alkylthio, alkylsulfinyle, alkyle, cyano, carboxyle, alcoxycarbonyle, aminocarbonyle, alkylaminocarbonyle, arylaminocarbonyle, N-alkyle-N-arylamonicarbonyle, haloalkyle, hydroxyle, alcoxy, hydroxyalkyle, alcoxyalkyle, haloalcoxy, amino, alkylamino, arylamino, hétérocyclo et nitro; R?4¿ représente haloalkyle, et R?5¿ est choisi entre alkyle et amino.

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