C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/4025 (2006.01) A61K 31/454 (2006.01) A61K 31/5377 (2006.01) A61P 25/28 (2006.01) C07D 207/16 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/06 (2006.01) C07D 413/14 (2006.01) C07D 491/04 (2006.01) C07D 491/107 (2006.01)
Patent
CA 2705745
The present invention is directed to 3,4-substituted pyrrolidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
La présente invention porte sur des composés de pyrrolidine 3,4-substitués représentés par la formule (I) qui sont des inhibiteurs de l'enzyme bêta-sécrétase et qui sont utiles dans le traitement de maladies dans lesquelles l'enzyme bêta-sécrétase est mise en jeu, telles que la maladie d'Alzheimer. L'invention porte également sur des compositions pharmaceutiques comprenant ces composés et sur l'utilisation de ces composés et compositions dans le traitement de maladies dans lesquelles l'enzyme bêta-sécrétase est mise en jeu.
Petrocchi Alessia
Stachel Shawn J.
Steele Thomas
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.p.a.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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