3,5,3'-triiodothyronine receptor ligands

Details 3,5,3'-triiodothyronine receptor ligands 3,5,3'-triiodothyronine receptor ligands

C - Chemistry, Metallurgy

07

D

C07D 307/79 (2006.01) A61K 31/055 (2006.01) A61K 31/135 (2006.01) A61K 31/34 (2006.01) C07C 39/367 (2006.01) C07C 217/22 (2006.01) C07C 225/16 (2006.01) C07D 307/80 (2006.01) C07D 307/81 (2006.01)

Patent

CA 2109625

Use of a compound seledod from the group consisting of 3,5-diiodo-4-(2-N,N- diethylaminoethoxy)phenyl-(2-butylbenzof- ur 3-yl)methanol hydrochloride (001), 2-methyl-3-(3,5-diiodo-4-(2-N,N- diethylaminoethoxy)-benzoyl)benzofuran hydrochloride (003), 2-n-butyl-3-(3,5-diiodo-4-carboxymethoxybenzoyl)benzofuran (005), 2- methyl-3-(3,5-diiodo-4-hydroxy-benzoyl)benzofur- aa (011), 2-methyl-3-(3,5-diiodo-4-carboxyinethoxybenzyl)benzofuran (015), 4'- hydroxy-3'-iodo-3,5-diiodo-4-(2-N,N-dimethy- laminodhoxy)benzophenon hydrochloride (024), 2-butyl-3-(3-iodo-4- hydroxybenzoyl)benzofuran (029), 4',4-dihydroxy-3'3,5-trii- odo.diphenylmethan (032), which compound is a 3,5,3'-triiodothymnine (T3) receptor tigand, for the preparation of a medicament for the therapeutic or prophylactic treatment of a disorder which depends on the expression of T-3 regulated genes, and pharmaoeutical preparations comprising said compounds, are disclosed. Further, a method of prophylactically or therapeutically treating a patient having a disorder which depends on the expression of 3,5,3'- triiodo-thyronine (T-3) regulated genes is also dis-closed. The invention additionally comprises product protection for all the above listed compounds, except the compound (011).

On décrit l'utilisation d'un composé choisi parmi le groupe suivant: hydrochlorure de 3,5-diiodo-4-(2-N,N-diéthylaminoéthoxy)phényl-(2-butylbenzofur-3-yl)méthanol (001); hydrochlorure de 2-méthyl-3-(3,5-diiodo-4-(2-N,N-diéthylaminoéthoxy)-benzoyl)benzofurane (003); 2-n-butyl-3-(3,5-diiodo-4-carboxyméthoxybenzoyl)benzofurane (005); 2-méthyl-3-(3,5-diiodo-4-hydroxy-benzoyl)benzofurane (011); 2-méthyl-3-(3,5-diiodo-4-carboxyméthoxybenzyl)benzofurane (015); hydrochlorure de 4'-hydroxy-3'-iodo-3,5 diiodo-4-(2-N,N-diméthylaminoéthoxy)benzophénone (024); 2-butyl-3-(3-iodo-4-hydroxybenzoyl)benzofurane (029); 4',4-dihydroxy-3'3,5-triiodo-diphénylméthane (032), ledit composé étant un ligand de récepteur de 3,5,3'-triiodothyronine (T-3), servant à la préparation d'un médicament pour le traitement thérapeutique ou prophylactique d'une affection qui dépend de l'expression de gènes à régulation T-3, ainsi que des préparations pharmaceutiques renfermant lesdits composés. De plus, on décrit une méthode de traitement prophylactique ou thérapeutique d'un patient atteint d'une affection qui dépend de l'expression de gènes à régulation 3,5,3'-triiodo-thyronine (T-3). Les produits dont la protection est également demandée sont tous les composés énumérés ci-dessus, à l'exception du composé (011).

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