3',5'-di-o-acylated nucleosides for hcv treatment

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 405/04 (2006.01) A61K 31/513 (2006.01)

Patent

CA 2647276

Compounds having the formula I wherein R1 is as herein defined are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis replication, processes for making the compounds and synthetic intermediates used in the process.

La présente invention concerne des composés répondant à la formule I, R1 étant tel qu'il est défini dans le présent document, utilisés en tant qu'inhibiteurs de la NS5b polymérase du virus de l'hépatite C. L'invention concerne également des compositions et des procédés permettant d'inhiber la réplication du virus de l'hépatite, des procédés de fabrication des composés et des intermédiaires de synthèse utilisés dans lesdits procédés.

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