3,5-di-tert-butylstyrene derivatives, salts thereof, and...

Details 3,5-di-tert-butylstyrene derivatives, salts thereof, and... 3,5-di-tert-butylstyrene derivatives, salts thereof, and...

C - Chemistry, Metallurgy

07

C

260/489, 260/315

C07C 49/747 (2006.01) C07C 49/248 (2006.01) C07C 49/753 (2006.01) C07C 49/835 (2006.01) C07C 59/52 (2006.01) C07C 59/90 (2006.01) C07D 233/96 (2006.01) C07D 307/58 (2006.01)

Patent

CA 1187505

ABSTRACT OF THE DISCLOSURE Novel compounds, 3,5-di-tert-butylstyrene derivatives and their salts, are disclosed, which derivatives are represented by the general formula: Image wherein R1 stands for an acyloxy group represented by R3 COO (R3 is a hydrogen atom or an alkyl group with C1 ? C6), an alkoxyl group of R40 (R4 is an alkyl group with C1 ? C4), a hydroxyl group, or a hydrogen atom; R2 stands for Image (R5 is a hydrogen atom or an alkyl group with C1 ? C3 and X1 is CH2 or an oxygen atom), Image (R5 and X1 are each the same as defined above), or Image (X2 is an oxygen or sulfur atom). There are also disclosed an anti-inflammatory, analgesic, and antipyretic pharmaceutical composition and an anti-platelet aggregation pharmaceutical composition, both pharmaceutical compostions comprising the foregoing 3,5-di-tert-butylstyrene derivative or its pharmaceutically acceptable salt as an active ingredient in association with pharmaceutical excipients.

395217

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