3,5-diamino-6-phenyl-1,2,4-triazines

Details 3,5-diamino-6-phenyl-1,2,4-triazines 3,5-diamino-6-phenyl-1,2,4-triazines

C - Chemistry, Metallurgy

07

D

260/248.6

C07D 253/06 (2006.01) C07C 51/15 (2006.01) C07C 51/363 (2006.01) C07C 51/60 (2006.01) C07C 281/18 (2006.01) C07D 253/075 (2006.01)

Patent

CA 1112643

ABSTRACT OF THE DISCLOSURE The present invention provides compounds of the formula (III): Image ( III ) or an acid addition salt thereof, wherein R6 is chlorine, bromine, iodine, C1-4 alkyl or trifluoromethyl, or R6 and R7 form a -CH=CH-CH=CH- group optionally substituted by a halogen atom or a C1-4 alkyl or trifluoromethyl group, R8 is hydrogen, bromine, iodine, C1-4 alkyl or trifluoromethyl, R9 is hydrogen, halogen, C1-4 alkyl or trifluoromethyl, R10 is hydrogen, methyl or fluorine and R11 is amino, C1-10 acylamino or di-substituted aminomethyleneamino provided that, at most, only two of R7-R10 are other than hydrogen and that R7-R10 are not all hydrogen when R6 is chlorine. Also provided are pharmaceutical compositions containing compounds of the formula (III), the first medical use of compounds of the formula (III), a process for preparing such compounds and intermediates through which this process proceeds.

353081

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