3,5-dihydroxypentanoic acid derivatives useful as...

Details 3,5-dihydroxypentanoic acid derivatives useful as... 3,5-dihydroxypentanoic acid derivatives useful as...

C - Chemistry, Metallurgy

07

D

167/234, 260/310

C07D 277/04 (2006.01) A61K 31/425 (2006.01) C07D 277/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2018469

HX25 Abstract 3,5-DIHYDROXYPENTANOIC ACID DERIVATIVES USEFUL AS ANTIHYPERCHOLESTEROLEMIC AGENTS AND METHOD FOR PREPARING SAME 3,5-Dihydroxypentanoic acid derivatives are provided which are 6-hydroxy-8-(2,2-dimethyl-1-oxy- butoxy-2-methyl)-substituted-thiazolidine derivatives and have the structure Image wherein Z is Image or Image HX25 R6 is an alkali metal, lower alkyl or H; R1 and R2 are the same or different and are H, lower alkyl or aryl; X is S, O, Image , Image or a single bond; R7 is lower alkyl; R3 is lower alkyl or aryl; R4 and R5 are the same or different and are H or lower alkyl; and --- represents a single bond or a double bond, and are HMG CoA reductase inhibitors and thus are useful as antihypercholesterolemic agents and in treating atherosclerosis, and also as antifungal agents. In addition, novel intermediates for use in preparing the above mevinic acid derivatives are also provided.

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