3,5-diphenyl-h-1,2,4-triazoles with contragestational...

Details 3,5-diphenyl-h-1,2,4-triazoles with contragestational... 3,5-diphenyl-h-1,2,4-triazoles with contragestational...

C - Chemistry, Metallurgy

07

D

260/313.3, 260/3

C07D 249/08 (2006.01) C07C 243/38 (2006.01) C07D 405/04 (2006.01)

Patent

CA 1181406

ABSTRACT 3,5-diphenyl-1H-1,2,4-triazoles with contragestational activity of the following formula Image wherein R may be located on one or the other of the two adjacent nitrogen atoms and may represent hydrogen or a group R5CO- wherein R5 is an aliphatic saturated or unsaturated hydrocarbyl containing from 1 to 20 carbon atoms, R1, R2 and R3, each independently are selected from hydrogen, lower alkyl and lower alkoxy or R2 and R3 together may represent a methylenedioxy group, and R4 is an aliphatic saturated or unsaturated hydrocarbyl group of from 1 to 20 carbons, with the proviso that when R is hydrogen or an R5CO- group wherein R5 contains 4 or less carbon atoms, R4 must contain 5 or more carbons. These compounds have proven to be highly effective in terminating pregnancy in several animal species after a single parenteral injection.

413769

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