3,5-disubstituted-1,3-oxazolidin-2-one derivatives

Details 3,5-disubstituted-1,3-oxazolidin-2-one derivatives 3,5-disubstituted-1,3-oxazolidin-2-one derivatives

C - Chemistry, Metallurgy

07

D

C07D 263/20 (2006.01) A61K 31/42 (2006.01) A61P 25/18 (2006.01) C07D 413/04 (2006.01) C07D 413/10 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2711123

The present invention is directed to 3,5-disubstituted-1,3-oxazolidin-2-one derivatives which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

La présente invention concerne des dérivés de 1,3-oxazolidin-2-one 3,5-substituée qui sont des agents de potentialisation des récepteurs de glutamate métabotropiques, notamment le récepteur mGluR2, et qui sont utiles dans le traitement ou la prévention de troubles neurologiques et psychiatriques associés à un dysfonctionnement du glutamate et de maladies dans lesquelles sont impliqués les récepteurs de glutamate métabotropiques. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et compositions dans la prévention ou le traitement de ces maladies dans lesquelles sont impliqués les récepteurs de glutamate métabotropiques.

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