3,5-disubstituted-1h-1,2,4-triazole derivatives

Details 3,5-disubstituted-1h-1,2,4-triazole derivatives 3,5-disubstituted-1h-1,2,4-triazole derivatives

C - Chemistry, Metallurgy

07

D

260/313.3, 260/3

C07D 405/10 (2006.01) C07D 249/08 (2006.01)

Patent

CA 1100511

ABSTRACT OF THE DISCLOSURE Novel 3,5-disubstituted-1H-1,2,4-trizoles of formula Image I wherein: R is selected from hydrogen, (C1-4) alkyl, (C1-4) alkoxy, allyloxy, propargyloxy, trifluoromethyl, phenyl, fluoro, chloro and dimethylamino; R1 represents a (C1-4) alkyl group; R2 is selected from hydrogen, fluoro, chloro, methoxy and ethoxy; R3 is selected from hydrogen, fluoro, chloro, (C1-4) alkyl and (C1-4) alkoxy; R and R3 taken together represent a methylenedioxy group; with the proviso that, when simultaneously R, R2 and R3 represent hydrogen, R1 cannot be methyl; with the further proviso that, when simultaneously R2 and one of R and R3 represent hydrogen, R1 and the other of R and R3 cannot simultaneously represent methyl; and salts therewith of pharmaceutically acceptable acids. The compounds possess anti-reproductive and CNS-utility.

302712

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