3, 5-disubstituted and 3,5,7-trisubstituted-3h-oxazolo and...

C - Chemistry – Metallurgy – 07 – H

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C07H 19/067 (2006.01) A61K 31/519 (2006.01) A61K 31/7064 (2006.01) A61P 31/14 (2006.01) A61P 37/02 (2006.01) C07D 513/04 (2006.01) C07H 19/167 (2006.01)

Patent

CA 2589529

The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3-H- oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and pharmaceutical compositions containing them, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds and prodrugs.

L'invention concerne des composés de -3-H-oxazolo and 3H-thiazolo[4,5-d]pyrimidine-2-one disubstitués en 3,5 et trisubstitués en 3,5,7 et des promédicaments associés qui possèdent une activité immunomodulatrice. Cette invention a aussi pour objet l'utilisation thérapeutique ou prophylactique de tels composés et des compositions pharmaceutiques les contenant, ainsi que des méthodes de traitement de maladies et de troubles décrits ci-après reposant sur l'administration de quantités efficaces de tels composés et promédicaments.

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