C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/04 (2006.01) A61K 31/416 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2532908
3,5 disubstituted indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating CDK dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
L'invention concerne des composés d'indazole 3,5 disubstitutés modulant et/ou inhibant la prolifération cellulaire, par exemple l'activité des protéines kinases. Ces composés et des compositions pharmaceutiques les contenant sont aptes à assurer la médiation des maladies CDK-dépendantes en vue de moduler et/ou inhiber la prolifération cellulaire non désirée. L'invention concerne également l'usage thérapeutique ou prophylactique desdites compositions pharmaceutiques, et des méthodes pour traiter le cancer ainsi que d'autres états pathologiques associés à une angiogenèse et/ou une prolifération cellulaire non désirées, par exemple la rétinopathie diabétique, le glaucome néovasculaire, la polyarthrite rhumatoïde et le psoriasis, par l'administration de quantités efficaces de tels composés.
Kephart Susan Elizabeth
Mcalpine Indrawan James
Reich Siegfried Heinz
Pfizer Inc.
Sim & Mcburney
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