3,5-disubstituted pyrid-2-ones useful as inhibitors of tec...

Details 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec... 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4418 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2620269

The present invention relates to pyrid-2-one compounds of formula (I) useful as inhibitors of Tec family (e.g. Tec, Btk, Itk/emt/Tsk, Bmx, Txk/Rlk) protein kinases. These compounds and pharmaceutically acceptable compositions thereof are useful for treating or preventing autoimmune, inflammatory, proliferative, hyperproliferative or immunologically-mediated diseases, wherein R2' is a ring; Q is 5-membered heteroaryl containing 1-4 nitrogen atoms, wherin one of the nitrogen atoms is NH; each Q is optionally substituted with 0-3 JQ and is optionally fused to ring Q1; each R3 and R4 is as described herein (Formula I).

La présente invention concerne des composés pyrid-2-one représentés par la formule (I) qui sont utiles en tant qu'inhibiteurs de la famille Tec (par exemple, Tec, Btk, Itk/emt/Tsk, Bmx, Txk/Rlk) des protéines kinases. Ces composés et les compositions pharmaceutiquement acceptables de ces derniers sont utiles pour traiter ou prévenir les maladies auto-immunes, inflammatoires, proliférantes, hyperproliférantes ou les maladies à médiation immunologique. Dans la formule (I), R2' représente un cycle; Q représente hétéroaryle à 5 chaînons contenant de 1 à 4 atomes d'azote, un de ces atomes d'azote représentant NH; chaque Q est facultativement substitué par 0-3 JQ et se trouve facultativement fusionné au cycle Q1; chaque R3 et R4 est tel que défini dans la formule (I). Formule I

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