3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec...

Details 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec... 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/444 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 401/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2620352

The present invention relates to pyrid-2-one compounds of formula (I) useful as inhibitors of protein kinase of Tec family (e.g., Tec, Btk, Itk/Emt/Tsk, Bmx,Txk/Rlk) protein kinases. These compounds and pharmaceutically acceptable compositions thereof are useful for treating or preventing autoimmune, inflammatory, proliferative, hyperproliferative or immunologically-mediated diseases.

L'invention porte sur des composés de pyrid-2-one de formule (I) utilisés comme inhibiteurs des protéines kinases de la famille TEC (par exemple Tec, Btk, Itk/Emt/Tsk, Bmx. Txk/Rlk. Ces composés, et des préparations pharmacocompatibles les contenant s'avèrent utiles dans le traitement ou la prévention de maladies auto-immunes, inflammatoires, prolifératives, hyperprolifératives ou médiées immunologiquement.

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