3,5-substituted aminobenzoylguanidines, process for their...

Details 3,5-substituted aminobenzoylguanidines, process for their... 3,5-substituted aminobenzoylguanidines, process for their...

C - Chemistry, Metallurgy

07

C

C07C 279/22 (2006.01) A61K 31/165 (2006.01) A61K 31/395 (2006.01) C07D 295/155 (2006.01)

Patent

CA 2111512

There are described benzoylguanidines of the formula I (see formula I) where one of the substituents R(1), R(2), R(3) or R(4) is: an amino group (see formula II) where R(5), R(6) = inter alia, H or alkyl, or alternatively R(5) and R(6), together with the nitrogen atom, are a 5-7-membered ring, and the other substituents R(1), R(2), R(3) and R(4) in each case are: H, Hal, CN, CF3, NO2, CF3-O-, C m F2m+1 -CH2-O-, R(11)-C q H2q -X p -, X = O or NR(12), R(11) = H, (cyclo)alkyl, phenyl, and where R(1) and R(4) are not simultaneously hydrogen. The compounds I have very good antiarrhythmic and cardioprotective properties, but no undesired salidiuretic properties. They additionally exhibit protective properties against ischemically induced damage in vivo and in vitro in different organs and gastroprotective properties as a result of inhibition of gastric acid secretion. Moreover, they are distinguished by inhibitory action on the proliferation of cells.

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