3-[(5-substituted benzyl)amino]-2-phenylpiperidines as...

Details 3-[(5-substituted benzyl)amino]-2-phenylpiperidines as... 3-[(5-substituted benzyl)amino]-2-phenylpiperidines as...

C - Chemistry, Metallurgy

07

D

C07D 211/56 (2006.01) A61K 31/445 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2193468

This invention provides a compound of the formula: (see fig. I) (I) and its pharmaceutically acceptable salts, wherein R1 is C1-C6 alkyl, C3-C6 cycloalkyl, halo C1-C6 alkyl or terahydropyranyl, having one or more substituents selected from cyano, 1,3-thiazolanyl, COOR2, COR2, OCOR2, CONR3R4, NR3R4, NR5COR3 and CCR6, wherein R2 is hydrogen or C1-C4 alkyl, R3 and R4 are independently hydrogen, C1-C4 alkyl or C3-C6 cycloalkyl, R5 is C1-C4 alkyl or C3-C6 cycloalkyl and R6 is hydrogen, halo, cyano, C1-C6 alkyl, COOH, COO(C1-C4 alkyl) or phenyl; X is C1-C6 alkoxy or halo C1-C6 alkoxy; and Ar is phenyl optionally substituted with halo. These compounds are useful in the treatment of allergic disorders, angiogenesis,gastrointestinal disorders, central nervous system disorders, inflammatory diseases, emesis, urinary incontinence, pain, migraine, sunburn, and diseases, disorders and adverse conditions caused by Helicobacter pylori, in a mammalian subject.

a présente invention donne un composé de formule : (voir fig. I) (I) et ses sels pharmaceutiquement acceptables où R1 est un groupe alkyle en C1-C6, cycloalkyle en C3-C6, haloalkyle en C1-C6 ou térahydropyranyle, ayant un substituant ou plus choisis parmi les groupements cyano, 1,3-thiazolanyle, COOR2, COR2, OCOR2, CONR3R4, NR3R4, NR5COR3 et C.

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