3,6-disubstituted azabicyclo [3.1.0]hexane derivatives...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 405/06 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61P 43/00 (2006.01) C07D 209/04 (2006.01) C07D 209/52 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2492121

This invention generally relates to the derivatives of novel 3,6 disubstituted azabicyclo[3.1.0] hexanes. The compounds of this invention are muscarinic receptor antagonists which are useful, inter-alia for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.

De manière générale, l'invention concerne des dérivés de nouveaux azabicyclo[3.1.0]hexanes 3,6-disubstitués. Les composés de l'invention sont des antagonistes des récepteurs muscariniques utiles, entre autres, dans le traitement de diverses maladies des systèmes respiratoire, urinaire et gastro-intestinal induites par l'intermédiaire des récepteurs muscariniques. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés ainsi que des méthodes de traitement des maladies induites par l'intermédiaire des récepteurs muscariniques.

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