C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/08 (2006.01) A61K 9/20 (2006.01) A61K 31/5386 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/38 (2006.01) A61K 47/40 (2006.01) A61P 9/06 (2006.01) A61K 9/19 (2006.01)
Patent
CA 2443473
There is provided immediate release pharmaceutical formulations comprising, as active ingredient, 4-({3-[7-(3,3-dimethyl-2-oxobutyl)-9-oxa-3,7- diazabicyclo[3.3.1]non-3-yl]propyl}amino)benzonitrile, tert-butyl 2-{7-[3-(4- cyanoanilino)propyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethyl-carbamate, tert-butyl 2-{7-[4-(4-cyanophenyl)butyl]-9-oxa-3,7-diaza-bicyclo[3.3.1]non-3- yl}ethylcarbamate or tert-butyl 2-{7-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]- 9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethylcarbamate, or a pharmaceutically- acceptable salt of any of these compounds, and a pharmaceutically-acceptable diluent or carrier. There is further provided solid pharmaceutical compositions comprising an above-stated active ingredient, which compositions are suitable for the preparation of immediate release pharmaceutical formulations, and which compositions may be prepared for example by freeze- drying. The formulations and compositions are useful in the prophylaxis and/or treatment of cardiac arrhythmias.
L'invention concerne des formulations pharmaceutiques à libération immédiate qui comprennent, comme principe actif, 4-({3-[7-(3,3-diméthyl-2-oxobutyl)-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl]propyl}amino)benzonitrile,<i> tert-</i>butyl 2-{7-[3-(4-cyanoanilino)propyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}éthyl-carbamate, <i>tert</i>-butyl 2-{7-[4-(4-cyanophényl)butyl]-9-oxa-3,7-diaza-bicyclo[3.3.1]non-3-yl}éthylcarbamate ou <i>tert</i>-butyl 2-{7-[(2<i>S</i>)-3-(4-cyanophénoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}éthylcarbamate, ou un sel pharmaceutiquement acceptable de l'un quelconque de ces composés et un diluant ou support pharmaceutiquement acceptable. L'invention concerne également des compositions pharmaceutiques solides contenant un principe actif tel que décrit. Ces compositions conviennent pour la préparation de formulations pharmaceutiques à libération immédiate et peuvent être préparées, par exemple, par lyophilisation. Les formulations et compositions de l'invention sont utiles pour la prophylaxie et/ou le traitement d'arythmies cardiaques.
Hovdal Christina
Lundgren Anna
Astrazeneca Ab
Fetherstonhaugh & Co.
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