C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/08 (2006.01) A61K 31/5386 (2006.01) A61P 9/06 (2006.01)
Patent
CA 2443470
There is provided substantially crystalline forms of 4-({3-[7-(3,3-dimethyl-2- oxobutyl)-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl]propyl}amino)benzo-nitrile; tert-butyl 2-{7-[3-(4-cyanoanilino)propyl]-9-oxa-3,7-diazabicyclo-[3.3.1]non-3- yl}ethylcarbamate; tert-butyl 2-{7-[4-(4-cyanophenyl)butyl]-9-oxa-3,7- diazabicyclo[3.3.1]non-3-yl}ethylcarbamate; or tert-butyl 2-{7-[(2S)-3-(4- cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo-[3.3.1]non-3- yl}ethylcarbamate and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of cardiac arrhythmias.
L'invention concerne des formes essentiellement cristallines de 4-({3-[7-(3,3-diméthyl-2-oxobutyl)-9-oxa-3,7-diazabicyclo[3.3.1]none-3-yl]propyl}amino)benzonitrile ; <i>tert</i>-butyl 2-{7-[3-(4-cyanoanilino)propyl]-9-oxa-3,7-diazabicyclo-[3.3.1]none-3-yl}éthylcarbamate ; <i>tert</i>-butyl 2-{7-[4-(4-cyanophényl)butyl]-9-oxa-3,7-diazabicyclo[3.3.1]none-3-yl}éthylcarbamate ; ou <i>tert</i>-butyl 2-{7-[(2<i>S</i>)-3-(4-cyanophénoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo-[3.3.1]none-3-yl}éthylcarbamate, ainsi que des sels pharmaceutiquement acceptables de ces composés. Les composés selon l'invention servent au traitement des arythmies cardiaques.
Barnwell Neil
Bjore Annika
Cheema Lal
Cladingboel David
Herring Adam
Astrazeneca Ab
Fetherstonhaugh & Co.
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