3,7-diazybicyclo [3.3.1] formulations as antiarrhytmic...

Details 3,7-diazybicyclo [3.3.1] formulations as antiarrhytmic... 3,7-diazybicyclo [3.3.1] formulations as antiarrhytmic...

C - Chemistry, Metallurgy

07

D

C07D 498/08 (2006.01) A61K 9/20 (2006.01) A61K 31/5386 (2006.01) A61P 9/06 (2006.01)

Patent

CA 2443464

There is provided a modified release pharmaceutical composition comprising 4- ({3-[7-(3,3-dimethyl-2-oxobutyl)-9-oxa-3,7-diazabicyclo-[3.3.1]non-3- yl]propyl}amino)benzonitrile, tert-butyl 2-{7-[3-(4-cyano-anilino)propyl]-9- oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethylcarbamate, tert-butyl 2-{7-[4-(4- cyanophenyl)butyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}ethylcarbamate, or tert-butyl 2-{7-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7- diazabicyclo[3.3.1]non-3-yl}ethylcarbamate, or a pharmaceutically-acceptable salt of any of these compounds, in particular a gelling polymer matrix modified release composition. The compositions are useful in the prophylaxis and/or treatment of cardiac arrhythmias.

La présente invention concerne une composition pharmaceutique à libération modifiée comprenant 4-({3-[7-(3,3-diméthyl-2-oxobutyl)-9-oxa-3,7-diazabicyclo-[3.3.1]non-3-yl]propyl}amino)benzonitrile, <i>tert</i>-butyl 2-{7-[3-(4-cyano-anilino)propyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}éthylcarbamate,<i> tert</i>-butyl 2-{7-[4-(4-cyanophényl)butyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}éthylcarbamate, ou <i>tert</i>-butyl 2-{7-[(2<i>S</i>)-3-(4-cyanophénoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}éthylcarbamate, ou un sel d'un de ces composés répondant aux normes pharmaceutiques. Cette invention concerne en particulier une composition à libération modifiée à matrice polymère gélifiante. Ces compositions conviennent pour la prophylaxie et/ou le traitement des arythmies cardiaques.

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