3-acylamino-2-oxo-1-azetidinyl-.beta.-oxypropionates

Details 3-acylamino-2-oxo-1-azetidinyl-.beta.-oxypropionates 3-acylamino-2-oxo-1-azetidinyl-.beta.-oxypropionates

C - Chemistry, Metallurgy

07

D

167/234, 167/241

C07D 205/08 (2006.01) A61K 31/425 (2006.01) C07D 205/085 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1243679

GC209 ABSTRACT 3-ACYLAMINO-2-OXO-1-AZETIDINYL-.beta.-OXYPROPIONATES Antibacterial activity is exhibited by (3-acylamino)-2-azetidinones having in the 1-position a group of the formula Image or a salt or ester thereof wherein R5 and R6 are the same or different and each is hydrogen, halogen, hydroxy, alkoxy, alkylthio, alkyl, substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, (cycloalkyl)- alkyl, (cycloalkenyl)alkyl, phenyl, substituted phenyl, phenylalkyl or (substituted phenyl)alkyl or together R5 and R6 can be ,CZ1Z2 Z1 and Z2 are the same or different and each is hydrogen, alkyl, phenyl, or substituted phenyl; and R7 is hydrogen and R8 is hydrogen, hydroxy, alkoxy, alkanoyloxy, or halogen, or together R7 and R8 can be =CZ1Z2.

462386

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