3-alkoxypyridine-2-carboxylic acid amide esters, their...

Details 3-alkoxypyridine-2-carboxylic acid amide esters, their... 3-alkoxypyridine-2-carboxylic acid amide esters, their...

C - Chemistry, Metallurgy

07

D

C07D 213/81 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2253282

Described are 3-alkoxypyridine-2-carboxylic acid amide esters of formula (I), wherein R1, R2 and R3 are hydrogen, R4 is a (C1-C6) alkyl, A is a -CH2 group in which one hydrogen can be replaced by a methyl group, and B is -CO2G, where G is the radical of a GOH alcohol, including the physiologically effective salts; their preparation, their use in inhibiting collagen biosynthesis, and their use as drugs for treating fibrotic diseases.

L'invention concerne des esters d'amide de 3-alcoxypyridine-2-acide carboxylique de la formule (I) dans laquelle R?1¿, R?2¿ et R?3¿ désignent hydrogène, R?4¿ désigne alkyle(C¿1?-C¿6?), A désigne un groupe -CH¿2? dans lequel un hydrogène peut être remplacé par un groupe méthyle, et B désigne -CO¿2?G, G désignant le reste d'un alcool GOH, y compris les sels à action physiologique. L'invention concerne leur préparation, leur utilisation pour inhiber la biosynthèse du collagène, ainsi que leur utilisation comme médicaments pour traiter des affections fibreuses.

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