C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/496 (2006.01) A61K 31/4985 (2006.01) A61P 3/10 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2683695
The present invention relates to compounds and pharmaceutically acceptable salts of Formula (I): wherein X, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined above. The invention further relates to pharmaceutical compositions comprising the compounds and pharmaceutically acceptable salts and to methods of treating diabetes mellitus and its complications (including in particular diabetic retinopathy, nephropathy or neuropathy), cancer, ischemia, inflammation, central nervous system disorders, cardiovascular disease, Alzheimer's disease and dermatological disease pression, viral diseases, inflammatory disorders, or diseases in which the liver is a target organ.
L'invention concerne des composés et des sels pharmaceutiquement acceptables de Formule (I) : dans laquelle X, R1, R2, R3, R4, R5, R6, R7 et R8 sont tels que définis dans la description. L'invention concerne également des compositions pharmaceutiques contenant ces composés et sels pharmaceutiquement acceptables, ainsi que des méthodes de traitement du diabète sucré et de ses complications (en particulier la rétinopathie, la néphropathie ou la neuropathie diabétiques), du cancer, de l'ischémie, des inflammations, des troubles du système nerveux central, des maladies cardiovasculaires, de la maladie d'Alzheimer, des maladies dermatologiques, des maladies virales, des troubles inflammatoires ou des maladies dans lesquelles le foie est un organe cible.
Botrous Iriny
Hong Yufeng
Li Hui
Liu Kevin Kun-Chin
Nukui Seiji
Pfizer Inc.
Smart & Biggar
LandOfFree
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