3-amino-2-oxo-1-piperidineacetic derivatives as enzyme...

Details 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme... 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme...

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) C07K 5/078 (2006.01) C07K 5/097 (2006.01)

Patent

CA 2192210

The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.

La présente invention concerne des aldéhydes de peptides qui sont des inhibiteurs puissants et spécifiques de la thrombine, leurs sels pharmaceutiquement acceptables, et des compositions pharmaceutiquement acceptables de ces derniers. L'invention a également pour objet des procédés pour les utiliser comme agents thérapeutiques pour soigner des maladies chez le mammifère, caractérisées par une thrombose anormale.

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