3-amino-2-oxo-1-piperidineacetic derivatives containing an...

Details 3-amino-2-oxo-1-piperidineacetic derivatives containing an... 3-amino-2-oxo-1-piperidineacetic derivatives containing an...

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 38/05 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2192211

The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.

L'invention concerne des aldéhydes peptidiques constituant des inhibiteurs puissants et spécifiques de la thrombine, leurs sels pharmaceutiquement acceptables, des compositions pharmaceutiquement acceptables de ceux-ci, et leurs procédés d'utilisation en tant qu'agents thérapeutiques pour les états pathologiques chez les mammifères caractérisés par une thrombose anormale.

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