C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/316, 260/389
C07D 403/06 (2006.01) C07D 207/34 (2006.01) C07D 295/18 (2006.01) C07D 498/04 (2006.01)
Patent
CA 1055036
Abstract of the Disclosure This invention relates to Image I wherein: R is selected from hydrogen, (C1-4) alkyl, benzyl, and halo-sub- stituted benzyl: R1 represents hydrogen, (C1-4) alkyl, phenyl or phenyl sub- stituted with 1 to 3 radicals independently selected from (C1-4) alkyl, (C1-4) alkoxy, benzyloxy, fluoro, chloro, bromo and hydroxy; R2 is a member of the class consisting of hydrogen, (C1-4) alkyl, formyl, (C2-4) aliphatic acyl, benzoyl, carbamyl, phemylcarbamyl, (C1-4) alkylsulfonyl, benzenesul- fonyl, toluenesulfomyl and phenacylsulfonyl; R3 is selected from hydrogen and (C1-4) alkyl; R4 and R5 independently represent hydrogen, or taken together with the adjacent nitrogen atom they can also represent dimethylamino or a 5-6 membered heterocyclic ring containing a further oxygen or nitrogen atom optionally substituted by one to three (C1-4) alkyl radicals or by a phenyl group; R6 represents a (C1-4) alkyl group; R2 and R3 taken together represent (C2-4) alkylidene, benzylidene or halo-substituted benzylidene and pharmaceutically acceptable acid addition salts thereof. It also relates to the preperation of these compounds according to known methods. The com- pound of formula I together with their pharmaceuticaly acceptable acid addition salts display very interesting pharmscological properties: more particul- arly, they are active as antlinflammatories, antipyretics and as prostaglan- din synthetase inhibitors. Furthermore, some of them display also interesting C.N.S. depressant and anti-hypertensive properties and possess a valuable degree of activity on the hydric balance of warm blooded animals. Certain of the internediates used in the preparation are new and form part of the present invention.
246109
Panzone Giambattista
Tarzia Giorgio
LandOfFree
3-amino-4-carbamyl-pyrrol derivatives and methods for their... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 3-amino-4-carbamyl-pyrrol derivatives and methods for their..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-amino-4-carbamyl-pyrrol derivatives and methods for their... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-824957