3-amino-4-phenylbutanoic acid derivatives as dipeptidyl...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61K 31/4985 (2006.01) A61K 31/5025 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01) A61P 3/10 (2006.01) C07D 217/06 (2006.01) C07D 217/26 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2513684

The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

La présente invention concerne des dérivés d'acide 3-amino-4-phénylbutanoïque qui sont des inhibiteurs de l'enzyme dipeptidyle peptidase-IV ("DP-IV inhibiteurs") et qui conviennent pour le traitement ou la prévention de maladies dans lesquelles cette enzyme dipeptidyle peptidase-IV est impliquée, telles que le diabète et, en particulier, le diabète de type 2. Cette invention concerne aussi des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et de ces compositions dans la prévention ou le traitement des maladies dans lesquelles cette enzyme dipeptidyle peptidase-IV est impliquée.

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