3-amino-4-phenylbutanoic acid derivatives as dipeptidyl...

A - Human Necessities – 61 – K

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A61K 31/4365 (2006.01) A61K 31/00 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2512546

The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

La présente invention concerne des dérivés d'acide 3-amino-4-phénylbutanoïque utilisés comme inhibiteur de la dipeptidyl peptidase-IV (<= inhibiteurs DP-IV >=) pour le traitement ou la prévention de maladies dans lesquelles la dipeptidyl peptidase-IV est impliquée, telles que le diabète et, plus précisément, le diabète de type 2. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et de ces compositions dans la prévention ou le traitement de ces maladies dans lesquelles la dipeptidyl peptidase-IV est impliquée.

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