C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61K 31/5377 (2006.01) A61K 38/55 (2006.01) A61P 7/12 (2006.01)
Patent
CA 2508947
The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
L'invention concerne des dérivés de 3-amino-4-phénylbutanoïque acide qui sont des inhibiteurs de l'enzyme dipeptidyl peptidase-IV (<= inhibiteurs DP-IV >=) et qui sont utiles au traitement ou la prévention de maladies dans lesquelles l'enzyme dipeptidyl peptidase-IV est impliquée, telles que le diabète, et notamment le diabète de type 2. Cette invention concerne aussi des compositions pharmaceutiques contenant ces composés, ainsi que l'utilisation des ces composés et compositions dans la prévention ou le traitement de ces maladies dans lesquelles l'enzyme dipeptidyl peptidase-IV est impliquée.
Duffy Joseph L.
Edmondson Scott D.
Kim Dooseop
Kirk Brian A.
Wang Liping
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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