A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01) A61P 3/10 (2006.01) C07D 491/00 (2006.01)
Patent
CA 2524531
The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
La présente invention concerne des dérivés d'acide 3-amino-4-phénylbutanoïque qui sont des inhibiteurs de l'enzyme dipeptidyl peptidase-IV ("inhibiteurs de DP-IV") et qui sont utiles dans le cadre du traitement ou de la prévention des maladies au cours desquelles l'enzyme dipeptidyl peptidase-IV est impliquée, telles que le diabète et en particulier le diabète de type 2. L'invention a également pour objet des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et de ces compositions pour la prévention ou le traitement de maladies de ce type au cours desquelles l'enzyme dipeptidyl peptidase-IV est impliquée.
Biftu Tesfaye
Feng Danqing Dennis
Liang Gui-Bai
Qian Xiaoxia
Gowling Lafleur Henderson Llp
Merck And Co. Inc.
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