3-amino-5-(pyridinyl)-2(1h)-pyridinone derivatives

Details 3-amino-5-(pyridinyl)-2(1h)-pyridinone derivatives 3-amino-5-(pyridinyl)-2(1h)-pyridinone derivatives

C - Chemistry, Metallurgy

07

D

260/279.4

C07D 401/04 (2006.01)

Patent

CA 1185242

ABSTRACT OF THE DISCLOSURE N-Hydroxy-1-R1-1,2-dihydro-2-oxo-5-PY-6-R-nicotinimidamides or pharmaceutically-acceptable acid-addition salts thereof, useful as cardiotonic agents, are preparsd by reacting 1-R1-1,2-dihydro-2-oxo-5-PY- 6-R-nicotinonitriles with hydroxylamine and are converted by reaction with polyphosphoric acid to the corresponding cardiotonically useful 1- R1-3-amino-5-PY-6-R-2(1H)-pyridinones, where R1 is hydrogen, lower-alkyl and lower-hydroxyalkyl, R is hydrogen or lower-alkyl, and PY is 4- or 3- pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents.

448189

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