C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01)
Patent
CA 2663943
The picsenl invention provides novel compounds represented by the general formula (I): wherein Ar is a quinoline or isoquinoline moiety which is substituted or unsubstituted; B is -O. -S-. or -NH-: R1 is hydrogen or S(O)2R4: R2 is S(O)2R4. C(O)OR5. or C(O)(CH2)n-C(O)OR6: R3 is halogen, cyano, C(O)OR7. or C(O)NR8R9: R4 is aryl: R5 is (C1-C6)alkyl or aryl: R6 is hydrogen. (C1-C4)alkyl. or aryl: R7 is hydrogen or (C1-C4)alkyl: R8 and R9 are independently hydrogen or (C1-C6)alkyl; n is an integer from 1-3: and a pharmaceutically acceptable salt or solvate thereof. their pharmaceutically acceptable salts and their pharmaceutically acceptable solvates thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia. The invention also relates to a process for the manufacture of compounds of formula (I) and pharmaceutical compositions containing them.
La présente invention concerne des composés représentés par la formule générale (I) et certains de leurs sels et solvates pharmaceutiquement admis, convenant pour le traitement de troubles du métabolisme en lien avec la résistance à l'insuline ou l'hyperglycémie. L'invention concerne également un procédé de fabrication des composés représentés par la formule (I) et des compositions pharmaceutiques les contenant.
Bajare Swapnil Ramesh
Deka Nabajyoti
Hariharan Sivaramakrishnan
Khan Taj Usman
Kulkarni Rhushikesh Arun
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Piramal Life Sciences Limited
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