3-aminoalkylamino-2h-1,4-benzoxazines and 3-aminoalkylamino-...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/12 (2006.01) A61K 31/54 (2006.01) C07D 265/36 (2006.01) C07D 279/16 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2307905

Disclosed are compounds of formula (I) or the pharmaceutically acceptable acid addition salts thereof, wherein: Ar represents aryl or heteroaryl; R1 and R2 are the same or different and represent organic or inorganic substituents; R5 is hydrogen or C1-C6 alkyl; W represents CH or nitrogen; X is oxygen or sulfur; and A represents an alkylene group, which compounds bind selectively with high affinity to the dopamine D4 receptor subtype and are therefore of use in treatment of various neuropsychological disorders.

La présente invention concerne des composés représentés par la formule générale (I) ou certains de leurs sels d'addition acides pharmaceutiquement admis. En l'occurrence, Ar est aryle ou hétéroaryle. R¿1? et R¿2?, qui sont identiques ou différents, sont des substituants organiques ou inorganiques. R¿5? est hydrogène ou C¿1?-C¿6? alkyle. W est CH ou azote. X est oxygène ou soufre. Enfin, A est un groupe alkylène. Se liant sélectivement avec une affinité élevée au récepteur de sous-type D¿4? de la dopamine, ces composés conviennent particulièrement au traitement de divers troubles neurophychologiques.

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