3-aminopyrazole inhibitors of cyclin dependent kinases

Details 3-aminopyrazole inhibitors of cyclin dependent kinases 3-aminopyrazole inhibitors of cyclin dependent kinases

C - Chemistry, Metallurgy

07

D

C07D 413/06 (2006.01) A61K 31/42 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2399274

The present invention describes compounds of Formula (I) and pharmaceutically acceptable salts thereof. The formula (I) compounds are protein kinase inhibitors and are useful in the treatment of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of Alzheimer's disease, and cardiovascular disease.

L'invention concerne les composés représentés par la formule (I) et des sels pharmaceutiquement acceptables de ces composés. Ces composés de formule (I) sont des inhibiteurs de protéine kinase et sont utiles pour le traitements de maladies prolifératives, comme par exemple les cancers, les inflammations et l'arthrite. Ces composés pourraient en outre être utiles pour le traitement de la maladie d'Alzheimer et des maladies cardio-vasculaires.

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