3-aminopyridazine derivatives active on the central nervous...

Details 3-aminopyridazine derivatives active on the central nervous... 3-aminopyridazine derivatives active on the central nervous...

C - Chemistry, Metallurgy

07

D

C07D 471/08 (2006.01) A61K 31/50 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 237/20 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 451/02 (2006.01) C07D 451/04 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2068770

PATENT APPLICATION entitled: Novel 3-aminopyridazine derivatives active on the central nervous system, method of preparation and pharmaceutical compositions in which they are present in the names of : Jean-Jacques BOURGUIGNON Jean-Paul KAN Camille Georges WERMUTH Assignee: ELF SANOFI ABSTRACT OF THE DISCLOSURE The invention relates to 3-aminopyridazine derivatives. These compounds have the formula Image (I) in which: - RV is a linear or branched C1-C4 alkyl group; - R6 is hydrogen, a C1-C3 alkoxy or a hydroxyl group; and - Z is a group Image in which: * n1 and n2 independently are zero or one, * Y1 and Y2 independently are hydrogen or a C1-C3 alkyl group, and * T is a dialkylamino group in which the alkyls are C1- C3, if Y1 or Y2 is other than hydrogen, or T is a heterocycle selected from: when n1 = n2 = 1 a) Image Y1 = CH3 and Y2 = H or Y1 = H andY2 = CH3 and W is an oxygen or sulfur atom when n1 = n2 = 1 b) Image Yl = Y2 = H and p is 2 or 3 ; when n1 = n2 = 0 c) Image and p is 2 or 3 and R = C1-C3 alkyl; when n1 = 1, n2 = 0 Y1 = H d) Image and p' and p" are 3 or 4 ; Application: drugs active on the central nervous system. No figure.

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