3-aminoquinazolin-2,4-dione antibacterial agents

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 239/96 (2006.01) A61K 31/505 (2006.01) A61P 31/04 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01) C07D 471/04 (2006.01) C07D 471/06 (2006.01) C07D 471/16 (2006.01) C07D 487/04 (2006.01) C07D 487/10 (2006.01) C07D 498/06 (2006.01) C07D 498/16 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2393802

Antibacterial 3-aminoquinazolin-2,4-diones have formula (I) wherein: R1 and R3 include alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclic, and heteroaryl; R5, R6, and R8 include H, alkyl, alkoxy, halo, NO2, CN, NH2, alkyl and dialkylamino; R7 includes hydrogen, alkyl, cycloalkyl, heterocyclic, fused heterocyclic, aryl and fused aryl; J and K are C or N; and pharmaceutically acceptable salts thereof.

L'invention concerne des 3-aminoquinazolin-2,4-diones antibactériennes correspondant à la formule (I), ainsi que des sels de celles-ci, acceptables sur le plan pharmacologique. Dans cette formule R¿1? et R¿3? comprennent alkyle, alcényle, alcynyle, cycloalkyle, aryle, hétérocyclique et hétéroaryle; R¿5?, R¿6?, et R¿8? comprennent H, alkyle, alcoxy, halo, NO¿2?, CN, NH¿2?, alkyle et dialkylamino; R¿7? comprend hydrogène, alkyle, cycloalkyle, hétérocyclique condensé, aryle et aryle condensé et J et K représentent C ou N.

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