3-aryl-4-alkyl and 4,5-dialkyl-4h-1,2,4-triazoles useful as...

Details 3-aryl-4-alkyl and 4,5-dialkyl-4h-1,2,4-triazoles useful as... 3-aryl-4-alkyl and 4,5-dialkyl-4h-1,2,4-triazoles useful as...

C - Chemistry, Metallurgy

07

D

C07D 249/08 (2006.01) A61K 31/41 (2006.01)

Patent

CA 2175352

This invention relates to the enhancement of memory and cognition and the treatment of Alzheimer's disease and Wernicke-Korsakoff syndrome by administration of 3-aryl-4-alkyl and 4,5- dialkyl-4H-1,2,4-triazoles of formula (I) wherein R1 and R2 independently represent hydrogen, halogen, trifluoromethyl, nitro, C1-4 lower alkyl or C1-4 lower alkoxy, or together, R1 and R2 represent -CH=CH-CH=CH-, forming a 1- or 2-naphthylenyl ring system; R3 represents hydrogen or C1-4 lower alkyl; and R4 represents C1-4 lower alkyl, benzyl, or benzyl substituted by one or two groups selected from halogen, trifluoromethyl, nitro, C1-4 lower alkyl or C1-4 lower alkoxy.

L'invention a pour objet l'amélioration de la mémoire et de la cognition et le traitement de la maladie d'Alzheimer et de l'encéphalopathie de Gayer-Wernicke par l'administration de 3-aryl-4-alkyl et 4,5-dialkyl-4H-1,2,4-triazoles de la formule (I). Dans cette formule, R¿1? et R¿2? représentent indépendamment l'hydrogène, un halogène, du trifluorométhyle, un groupe nitro, un alcoyle inférieur C¿1-4? ou un alcoxy inférieur C¿1-4? ou R¿1? et R¿2? représentent ensemble -CH=CH-CH=CH-, formant un système de cycle 1- ou 2-naphtylényle; R¿3? représente l'hydrogène ou un alcoyle inférieur C¿1-4?; et R¿4? représente un alcoyle inférieur C¿1-4?, un benzoyle, ou un benzoyle avec substitution par un ou deux groupes sélectionnés parmi : halogène, trifluorométhyle, nitro, alcoyle inférieur C¿1-4? ou alcoxy inférieur C¿1-4?.

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