3-aryl-5,6-disubstituted pyridazines

Details 3-aryl-5,6-disubstituted pyridazines 3-aryl-5,6-disubstituted pyridazines

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/501 (2006.01) A61K 31/502 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) C07D 403/14 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2564996

The present invention provides compounds of Formula (I) or (II) salt form or prodrug thereof, wherein variables are defined herein, that are modulators of metalloproteases such as matrix metalloproteases (MMPs) and ADAMs. The compounds or compositions described herein can be used to treat diseases associated with metalloprotease activity including, for example, arthritis, cancer, cardiovascular disorders, skin disorders, inflammation or allergic conditions.

La présente invention a trait à des composés de formule (I) ou (II) dans lesquelles les variables sont tels que définis dans la demande, et une forme de sel ou prodrogue de ceux-ci, qui sont modulateurs des métalloprotéases telles que des métalloprotéases matricielles (MMP) et ADAM. Les composés et les compositions de l'invention peuvent être utilisés pour le traitement de maladies associées à l'activité de métalloprotéase comprenant, par exemple, l'arthrite, le cancer, les troubles cardio-vasculaires, les troubles cutanés, l'inflammation ou des conditions allergiques.

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