3-aryl-5-alkylthio-4h-1,2,4-triazoles

Details 3-aryl-5-alkylthio-4h-1,2,4-triazoles 3-aryl-5-alkylthio-4h-1,2,4-triazoles

C - Chemistry, Metallurgy

07

D

167/208, 260/313

C07D 249/12 (2006.01) A61K 31/41 (2006.01) C07D 401/04 (2006.01) C07D 409/02 (2006.01) C07D 409/04 (2006.01)

Patent

CA 1312605

ABSTRACT This invention relates to derivatives of 3-aryl-5- alkylthio-4H-1,2,4-triazoles of the formula: Image or a pharmaceutically acceptable salt thereof, wherein Ar is phenyl, naphthyl, or a monocyclic heteroaryl moiety selected from thienyl, pyrrolyl, and N-(C1-6 lower alkyl)pyrrolyl; R1 is C1-6 lower alkyl; R2 is hydrogen or C1-6 lower alkyl; R is C1-6 lower alkyl, C1-6 alkoxy, hydroxy, halogeno, or trifluoromethyl and n is zero, 1 or 2, or Rn-(Ar) is methylenedioxyphenyl; and each of m and q is zero, 1 or 2; to their pharmacological properties and to their use as muscle relaxants, spasmolytics, anticonvulsants and anxiolytics.

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