3-aryl oxazolidinone derivatives, a method of preparing them...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/12 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 263/24 (2006.01)

Patent

CA 2065962

-42- Title: "3-aryl oxazolidinone derivatives, a method of preparing them and therapeutic use thereof" Inventors: Francois-Xavier JARREAU Jean-Jacques KOENIG Vincenzo ROVEI Applicants: DELALANDE S.A. (sociéhé anorlyme) A B S T R A C T Derivatives having the formula: Image (I) where R1 denotes C1-C4 alkyl; X denotes oxygen or methylene; R2 denotes C1-C4 alkyl or CF3; R3 denotes a CH2R4 group in which R4 is (i) a pentagonal or hexagonal aromatic heterocyclic group comprising one or two nitrogen atoms and optionally fused with a benzene ring or (ii) a group having the formula Image -43- where n = 0 or 1, and R5 and R6 independently denote C1-C4 alkyl or benzyl, and R5 and R6 also, together with the nitrogen atom to which they are bonded, form a piperidino or pyrrolidino or morpholino or N-methyl piperazino radical, and their N-oxide if any and acid addition salts of these derivatives and N-oxide, the derivatives being in various stereoisomeric forms or in the form of a mixture of these forms, including the racemic form. Of use in human or animal therapy.

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