3-arylamino pyridine derivatives

Details 3-arylamino pyridine derivatives 3-arylamino pyridine derivatives

C - Chemistry, Metallurgy

07

D

C07D 213/79 (2006.01) A61K 31/44 (2006.01) A61P 35/00 (2006.01) C07D 213/81 (2006.01)

Patent

CA 2582247

The invention provides novel, substituted 3-arylamino pyridine compounds (I) pharmaceutically acceptable salts, solvates and prodrug compounds thereof, wherein W, R1, R2, R9, R10, R11, R12, R13, R14 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation. Also disclosed is the use of such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and pharmaceutical compositions containing such compounds.

La présente invention se rapporte à de nouveaux composés de 3-arylamino pyridine substitués, à des sels pharmaceutiquement acceptables, à des solvates et à des composés promédicaments de ceux-ci, W, R1, R2, R9, R10, R11, R12, R13 et R14 étant tels que définis dans le descriptif de l'invention. De tels composés sont des inhibiteurs de MEK, et sont utiles pour traiter des maladies hyperprolifératives telles que le cancer, la resténose et l'inflammation. L'invention a également trait à l'utilisation de tels composés pour traiter des maladies hyperprolifératives chez les mammifères, en particulier chez les êtres humains, et à des compositions pharmaceutiques contenant de tels composés.

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