3-arylcarbonyl-1-aminoalkyl-1h-indole-containing...

Details 3-arylcarbonyl-1-aminoalkyl-1h-indole-containing... 3-arylcarbonyl-1-aminoalkyl-1h-indole-containing...

A - Human Necessities

61

K

167/208, 260/246

A61K 31/395 (2006.01) C07D 209/12 (2006.01) C07D 413/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2036307

Disclosed are antiglaucoma compositions containing 3-arylcarbonyl-1-aminoalkyl-1H-indoles of the formula: Image [wherein R2 is H, Cl, F or alkyl; R3 is (substituted) phenyl, benzyl,(substituted)styryl, (substituted) naphthyl, naphthyl- ethenyl, tetrahydronaphthyl, anthryl, phenanthryl, pyrenyl, benzofuryl, benzothienyl, benzimidazolyl or quinolyl; R4 is H, alkyl, alkoxy, hydroxyl or halo; Z is O or S; Alk is (alkyl-substituted) alkylene; and N=B is dialkylamino, (substituted) morpholinyl, pyrrolidinyl (substituted) piperi- dinyl] as an active component thereof, and useful in the treatment of glaucoma. Some of the compounds are novel.

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