3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles

Details 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles

C - Chemistry, Metallurgy

07

D

167/208, 260/279

C07D 403/06 (2006.01) A61K 31/395 (2006.01) C07D 401/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2035711

22749-366 D.N. 7438A ABSTRACT OF THE DISCLOSURE Disclosed are 2-R2-R4-substituted-3-R3-CO-l-[(C- attached-N heteryl)-(Alk)n]-lH-indoles of the formula: Image [wherein: R is H or alkyl; R is optionally substituted phenyl, biphenyl or optionally substituted naphthyl; R4 is H or substituent; Alk is alkylene; Het is aliphatic heterocycle that is attached at a ring carbon atom, such as pyrrolidinyl, piperidinyl, morpho- linyl, thiomorpholinyl, tetrahydropyridinyl, azetidinyl, hexa- hydroazepinyl, hexahydrothiazepinyl, piperazinyl or indolinyl, and n is 0 or 1, provided that n is not 0 when Alk is attached to a ring carbon atom adjacent to a ring N, O or S atom of the Het group] and their pharmaceutically acceptable acid addition or quaternary ammonium salts that are useful as analgesic, anti- rheumatic, antiinflammatory or anti-glaucoma agents.

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