3-aryloxazolidinone derivatives, process for their...

Details 3-aryloxazolidinone derivatives, process for their... 3-aryloxazolidinone derivatives, process for their...

C - Chemistry, Metallurgy

07

D

167/235, 260/304

C07D 263/24 (2006.01) A61K 31/42 (2006.01) C07D 405/02 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2027782

The derivatives of the formula : Image (I) wherein : - R1 is H or C1-C4 alkyl; X is an oxygen atom, a methylene group or a -CH=CH- group ; - n is 1 or 2 when X is an oxygen atom or a methylene group and is 0 or 1 when X is a -CH=CH- group ; - R3 is a C1-C4 alkyl, C3-C7 cycloalkyl, phenyl, benzyl, CHF2, CF3 or CF3CF2 group ; - each of R2 and R'2 independently is a hydrogen atom or a C1-C4 alkyl, C4-C7 cycloalkyl, phenyl or benzyl group ; - R'2 and R3 may further form together a -(CH2)3- or -(CH2)4- chain ; and - each of R4 and R'4 independently is a C1-C4 alkyl group or R4 and R'4 form together either a -(CH2)2- or -(CH2)3- chain, a -(CH2)2- or -(CH2)3- chain substituted by one or two C1-C4 alkyl groups, or a -(CH2)2- chain substituted by one or two -CH2-NH2 groups or by one or two -CH2-NH2 groups N-substituted by one or two C1-C4 alkyl groups, useful as anxiolytics and antidepresants.

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